I'm reading through Michael Stackpole's blog--of course I'd heard about it and read a post here and there (there's been some controversy because he refers to people like Scott Turow as "house slaves"), but this is my first concentrated go-through.
Anyway, he has a nice post on crappy e-book design that's worth a look. But I really liked this post about the need to adapt to e-books: Stackpole notes that since Barnes & Noble now sells the Nook as well as e-books, that means if a customer walks into a B&N and can't find the book they want, the clerk will say, Well, gee, we could special order it for you (which will take forever and you'll have to come back and won't that be a huge pain), or you could instantly and easily buy the e-book on your Nook!
So, the largest brick-and-mortar bookstore chain in the United States has a vested interest in promoting e-books. Quoth Stackpole:
With this being the case, if you don’t have work in the marketplaces toward which readers are being directed, you are out of the game.