I finished the first eight chapters (two yesterday, six today) of the large-print edition. It's going OK, but there's a little bit of a hitch. Per the AAPH guidelines, you're supposed to have a certain amount of space between lines, as well as a line space between paragraphs.
The problem is that the amounts I chose don't quite line up. So, if you have a spread with a bunch of paragraph breaks on the left-hand side and long text blocks on the right, the bottom lines don't quite line up. I realized this a few chapters in, so going back and fixing the spacing would be a big pain. Instead I'm cheating by slightly stretching the text on one side and smooshing it down on the other--hopefully it won't be noticeable!
(And the nice thing about real layout software is that it lets you do that sort of thing....)